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Dopamine and All That Jazz: Your brains reward system, largely governed by dopamine, might be getting a bit too excited by Ozempic

The combination of GLP-1RAs and metformin appears to be superior to any single agent in reducing body weight, hyperandrogenaemia, IR, and ovulation disorders in women with PCOS and may even improve metabolic outcomes in women who previously had an inadequate response to metformin [162, 217]

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Women of childbearing potential taking an oral hormonal contraceptive should add a barrier contraceptive for 4 weeks after starting tirzepatide and after each dose escalation

Gli autori stessi interpretano questi dati con cautela, attribuendoli almeno in parte a unintensificazione diagnostica nei pazienti trattati: i sintomi gastrointestinali tipici della classe inducono pi frequentemente esami tiroidei e colonscopie, e questo pu generare segnali apparenti di maggiore incidenza che riflettono maggiore sorveglianza, non maggiore malattia