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However, human studies are limited, and clinical significance remains uncertain compared to lifestyle interventions

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Encouraged by these results, Novo Nordisk launched the much larger SOUL trial the following year

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Officially, improving insulin sensitivity is attempted by means of medication, mainly metformin, recommended even for prevention, given the increasing insulin resistance in the pathogenesis of diabetes (73, 84)

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While the exact time may vary, the weekly schedule should remain as stable as possible to achieve optimal results [14]

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sitagliptin 50 mg bid with metformin HCl immediate-release 500 mg bid, -1.6%

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