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However, human studies are limited, and clinical significance remains uncertain compared to lifestyle interventions

Encouraged by these results, Novo Nordisk launched the much larger SOUL trial the following year

Officially, improving insulin sensitivity is attempted by means of medication, mainly metformin, recommended even for prevention, given the increasing insulin resistance in the pathogenesis of diabetes (73, 84)

While the exact time may vary, the weekly schedule should remain as stable as possible to achieve optimal results [14]

sitagliptin 50 mg bid with metformin HCl immediate-release 500 mg bid, -1.6%