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Researchers examine how this multi-receptor engagement may influence nutrient signaling, energy expenditure, and hormonal coordination in experimental systems

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The presence of GLP-1R in MCs has been confirmed by multiple research groups, including our own 5,15,16 and ex vivo data have shown that MCs increase their action potential firing frequency after the addition of both GLP-1 and the GLP-1R agonist exendin-4 17

The study used a cohort of over 5,000 randomly selected individuals from the PharMetrics Plus for Academics Database of over 16 million prescription drug users in the United States