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Geopolitical factors, such as trade agreements, intellectual property rights, and the stability of international supply chains for pharmaceutical ingredients, can also impact the manufacturing and distribution of GLP-1 receptor agonists globally

doi: 10.1002/path.5056

This has knock-on implications for patent filings and life-cycle management of the small-molecules in this space

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(146) observed significant blood-to-brain influx for non-acylated GLP-1 mimetics like exendin-4 and lixisenatide, whereas acylated GLP-1 analogues such as liraglutide and semaglutide showed minimal blood-brain barrier penetration in mice