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Based on several clinical studies documenting the effects of liraglutide, a long-lasting GLP-1RAs, on weight loss, it has been approved for the treatment of obesity at a dose of 3.0 mg/day in the form of subcutaneous injections [88]

Furthermore, patients treated with the dual GLP-1R and GIP agonist tirzepatide exhibited lower Food Craving Inventory scores for sweets and high-fat fast foods compared to those receiving liraglutide, indicating a greater reduction in desire for these items during weight loss (Martin et al., 2025)

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In 1992, Eng published his discovery of this novel peptide in the Journal of Biological Chemistry , naming it exendin-4

The study additionally showed that ROSE-010 was most helpful at relieving pain in IBS-C and IBS-M (43)