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ArakawaMMitaTAzumaKEbatoCGotoHNomiyamaTet alInhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4

Clinical studies have demonstrated that, when combined with a reduced-calorie diet and increased physical activity, semaglutide can lead to substantial and sustained weight loss

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Although oral semaglutide might be a better option for patients who are allergic to injections or reluctant to self-inject, its efficacy may be limited by its stringent administration guidelines, which call for taking it half an hour before the first meal, drink, or other medication [90]

Summary and outlook A summary of the relative risk of adverse events associated with GLP-1RAs is presented in Table 1
