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Here, we longitudinally profiled hepatic disease stages in GAN DIO-NASH mice, a translational model widely used in preclinical research and drug discovery for NASH 18,19,20

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in this regard, animal studies with early administration of GLP-1RA and long-term follow-up are needed, since fibrosis is a longitudinal progress, before this hypothesis is investigated in relevant clinical trials with NAFLD patients without significant hepatic fibrosis

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