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Early data suggests that while retatrutide produces more dramatic weight loss, the gastrointestinal side effect patterns may differ from those seen with semaglutide alone

1 Effect of semaglutide treatment or placebo on waist circumference from baseline to week 104 by subgroups

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General eligibility in UK practice For orlistat , UK prescribing has traditionally sat more comfortably in routine weight management care, particularly where BMI and obesity-related risk meet standard prescribing criteria

Rybelsus , which also belongs to the GLP-1 category, is a daily oral medication for adults with type 2 diabetes that uses the same active ingredient as Ozempic