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The most pronounced inhibitory effects were observed at concentrations of 10 and 100 nM for each compound

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These factors create a complex environment where multiple pathways contribute to atrial fibrillation development

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Several meta-analyses of RCTs have indicated that GLP-1RAs exert a neutral or potentially protective effect on AF

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The protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) under the registration number CRD420251039831

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