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Comprehensive, meticulously planned clinical trials that assess the outcomes of GLP-1RA-induced anti-inflammatory properties in various patient groups are essential

While many symptoms improve over time, GI discomfort remains a leading reason for discontinuation, reinforcing the need for gradual dose titration, patient education, and a personalized approach when choosing a GLP-1 therapy

Scott Steele: Butts & Guts, a Cleveland Clinic podcast exploring your digestive and surgical health from end to end

Orforglipron significantly improved those parameters compared with controls

households have at least one GLP-1 user as of December 2025, up from 9% the year before, said Furman