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Overall, the cost to treat each 1% reduction of body weight was $985 with tirzepatide and $1845 with semaglutide

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Despite the efficacy of GLP1 receptor agonists in reducing body weight, limited data exist on their impact on body composition, including changes in fat mass, lean mass, muscle function, and the potential development of sarcopenia defined by a loss of muscle mass and function

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doi: (Of importance) This cross-sectional study provides direct evidence that GLP-1 receptor agonist use may be accompanied by reduced intake of protein and selected micronutrients