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However, the rapid inactivation of GLP-1 by DPP-4 in vivo limits its application in clinic

Do you have a positive outlook

[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Deanfield J., Lincoff A.M., Kahn S.E., Emerson S.S., Lingvay I., Scirica B.M., Plutzky J., Kushner R.F., Colhoun H.M., Hovingh G.K., et al

Semaglutide, the active ingredient in Novo's Wegovy and Ozempic, and tirzepatide, sold as Zepbound and Mounjaro by Lilly, are so effective that they should be the first choice in almost all cases when substantial weight loss is necessary, according to a new guideline from the European Association for the Study of Obesity published in Nature Medicine

Cons: Still expensive even as the affordable option