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A degradation of extracellular ATP to adenosine diphosphate (ADP) is mediated enzymatically by ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) in type I cells, which in turn increases the response to sweet stimuli by binding of ADP to adenosine 2B (A2B) receptors in type II cells [39]

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Most examined studies did not enroll participants with diagnosed psychiatric disorders or evaluate structured psychiatric outcomes as primary endpoints