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To help provide insights into the potential role of oral semaglutide in current T2D management, this article aims to discuss the pharmacology of oral semaglutide, review the current clinical evidence on the efficacy and safety of this agent from the extensive phase III PIONEER clinical trial program in patients with T2D, and describe findings from initial cost-effectiveness studies

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Gottlieb, University of the Incarnate Word, United States Isabelle Runkle De La Vega, San Carlos University Clinical Hospital, Spain Oskar Ragnarsson, University of Gothenburg, Sweden Koro Gotoh, Oita University, Japan Updates Copyright 2026 Long and Azizan