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Commenting on the results, Ania Jastreboff, M.D., Ph.D., Professor of Medicine & Pediatrics (Endocrinology) at the Yale School of Medicine, Director of the Yale Obesity Research Center (Y-Weight), and lead investigator, said: It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost on average 30% of their body weight over two years

Rushing through the titration schedule often means more severe GI symptoms, worse adherence, and sometimes temporary discontinuation, which ultimately slows progress

The Food and Drug Administration (FDA) has received hundreds of reports of suicidal thoughts and depression from patients on weight loss medications since 2010, as well as 36 deaths 'by suicide or suspected suicide'
