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Weight Regain After Discontinuation All GLP-1 medications show substantial weight regain when stopped

Every medication, even those with promising benefits, comes with considerations

This is a crucial finding, as Metabolic Dysfunction-Associated Steatohepatitis (MASH) is a major driver of chronic disease and shortened healthspan

In recent years, a number of drugs have emerged that have significant cardio-renal protective effects in patients with diabetes, and a typical example is sodium-glucose cotransporter 2 inhibitor (SGLT2i), glucagon-like peptide-1 receptor agonist (GLP-1RA), and nonsteroidal mineralocorticoid receptor antagonist, finerenone

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