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For users on tirzepatide monotherapy, blood sugar related sleep disruption is usually mild and resolves as the body adapts to the new metabolic patterns, typically within 2-4 weeks of starting or increasing the dose

However, discontinuing treatment may result in gradual weight regain

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Although reaction-site issues like redness or tenderness resolve within a day or two, injection in the same spot every time can cause those reactions to be more intense or last longer, she says

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