surmount-2 tirzepatide type 2 diabetes weight loss results 2023 2024 cuts risk by 94% in SURMOUNT-1 trial Subcutaneously administered tirzepatide vs semaglutide
Description
At week 112, mean weight change from baseline was 22.4% with MTD (representing 100% maintenance prior to weight reduction), 17.0% with 5mg (~70% maintenance), and 10.1% with placebo

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Abstract Tirzepatide, a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, represents a new class of incretin-based therapy for type 2 diabetes mellitus (T2DM), obesity, and related comorbidities
