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Other notable greenlights this year include Bristol Myers Squibbs Cobenfy, the first novel therapeutic for schizophrenia in 35 years, and Madrigal Pharmaceuticals Rezdiffra, the first-ever treatment for MASH.

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Here, we investigated the role of three C-terminal serine doublets (Ser441/442, Ser444/445, Ser451/452) in the human receptor using site-directed mutagenesis in INS-1 832/3 -cells deleted for endogenous GLP-1R expression