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This rebound occurs because GLP-1 medications work by resetting appetite regulation in the brainstopping the medication doesn't maintain those changes

The trabecular density of GLP-1R and GIPR double KO mice was higher than that of the wild-type control group, but the cortical thickness, cortical area, and external diameter of bone decreased (Mieczkowska et al., 2015)

In a 2021 clinical trial, some participants lost more than 2% of their body weight within 4 weeks

Lisdexamfetamine (Vyvanse) is the only medication specifically approved for moderate to severe BED in adults, typically used alongside psychotherapy

[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Sun, X