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Organ tropism can be fine-tuned by altering nanocarrier lipid tail length, pKa, or incorporating selective organ targeting (SORT) motifs to redirect biodistribution away from hepatic default accumulation and toward extrahepatic sites such as adipose tissue or the CNS [461, 462]

Notably, bowel obstruction events were reported in 8% of patients treated with liraglutide, whereas no such events were observed among those receiving semaglutide (7)

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