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Patient-derived human islets from male and female cadaveric donors were 3D-cultured in solubilised extracellular matrix gel in co-culture with the same donor PBMCs, and incubated with cytokines (IL-1, TNF-, IFN-) for 2448 h in the presence of vehicle or increasing concentrations of the CB1R blocker JD-5037

Ideal candidates include people with a BMI of 30 or higher, type 2 diabetes, weight-related conditions or obesity.
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It removes latent GDF-8 from plasma and tissues and has the potential to improve symptoms associated with muscle atrophy and muscle weakness
