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Abstract Current gold standard therapeutic strategies for T2DM target insulin resistance or cell dysfunction as their core mechanisms of action
26 27 Additionally, GLP-1-mediated modulation of pain pathways, particularly via microglial activation in the caudal trigeminal nucleus, may exacerbate central sensitization and worsen headache symptoms

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The future of obesity treatment will not depend only on discovering new molecules, but also on developing smarter and more patient-friendly ways to deliver them
