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(2025) 48:S26682

While some supplement ingredients have shown promise in limited studies related to metabolic health and weight management, they do not have the same effects as GLP-1 drugs, Ventura said

Moreover, depression is characterized by high prevalence of coexistence with many metabolic diseases, such as type 2 diabetes mellitus (T2DM) and obesity, and brain insulin resistance observed in both of these diseases is currently considered an important factor which may lead to the manifestation of depressive symptoms [10, 11]

Some supplements may help support your bodys natural GLP-1 response, but none can truly replicate the effects of prescription GLP-1 medicationseven those with GLP-1 in the name

Conclusively, research on GLP-1R and its agonists marks a promising direction in metabolic disease therapy, extending their potential beyond glucose regulation and offering hope for more comprehensive approaches in addressing metabolic diseases