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The 12mg dose group in the Phase 2 trial had substantially more GI side effects than the 4mg group
"Triple-Hormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial." New England Journal of Medicine 2023;389:514526 Wilding JPH, et al
The pattern of this elevation was somewhat sexdivergent, where in males SEMA simply rescued the massive TH fiber depletion resulting from caloric restriction, whereas in females a trend to elevated TH in the SEMA group was found
