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Adiponectin also decreases hepatic de novo glucose production and reduces free fatty acid levels in the liver (196), thereby mitigating hepatic steatosis, enhancing insulin sensitivity, and improving the circulating lipid profile ( Figure 1 Section E)

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J Biol Chem 2000

Many women with PCOS qualify due to insulin resistance, cravings, or blood sugar crashes even without a diabetes diagnosis

This threshold is set because the risk-benefit profile of orlistat is considered favourable only when a meaningful degree of excess weight is present
