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Crumm, S., Cofan, M., Juskeviciute, E

As per Bradford Hills criteria 41 , the biological plausibility through GLP-1R expression in the nervous system and temporal consistency in time-to-onset analysis support potential causality, but confounding factors inherent to spontaneous reporting systems preclude definitive conclusions

Validated mapping places the receptor in the arcuate and paraventricular nuclei of the hypothalamus, the area postrema, and the nucleus of the solitary tract in the brainstem, regions that govern hunger, satiety, and nausea

The STEP 4 trial found that stopping semaglutide led to partial weight return even when lifestyle changes persisted, indicating medication plays a structural metabolic role

Sowa emphasizes as critical for long-term success