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Subtle dynamics allows the C-terminal of the ligand to access the ECD binding site, and the binding of the ligand triggers further dissociation between the ECD and TMD, allowing the N-terminal to enter the orthosteric pocket in the TMD and activate the receptor

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In particular, GLP-2 increases fasting plasma triglyceride level, very low-density lipoprotein (VLDL) production and hepatic lipogenesis, thereby leading to hepatic steatosis 7

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But access to the drugs has been a consistent problem for patients because of their cost around $500 a month for higher doses and insurance coverage has been spotty