glp-1/gip/glucagon triple agonist name Review Article: GLP‐1 Receptor Agonists and Glucagon/GIP/GLP‐1 Receptor Dual or Agonists—Mechanism of Action and Emerging Therapeutic Landscape in MASLD Science Behind GLP 1 GIP

These are considerable weight losses: in the 2 studies, the average weight of the participants was around 110 kg

doi: 10.2337/db13-1440

Exenatide reduces TNF-alpha expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats

However, whether a protein of such size could infiltrate the bloodbrain barrier to bind GLP-1R and GIPR in the brain, and whether receptors in the brain are important to the therapeutic effect, still need to be elucidated

Advancing our understanding and treatment of this comorbidity holds the potential to substantially improve quality of life and health outcomes for individuals living with these conditions