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Triple-hormone-receptor agonist retatrutide for obesity: a Phase 2 trial

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Conservative measures are aimed at softening the stool, relieving pain and correcting bad toileting habits

Yes, GLP-1 medications are FDA-approved for weight loss in addition to helping manage type 2 diabetes

In agreement, GLP1R agonists have been reported to reduce hepatocarcinogenesis in non-obese chemical carcinogen-induced mouse models of HCC, perhaps by limiting liver pro-tumorigenic metabolic factors such as hepatic insulin resistance, steatosis and inflammation 90,91