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Also, the inhibition of HDAC by SCFAs can further modulate the function of intestinal macrophages (Chang et al., 2014) and dendritic cells (Trompette et al., 2014

It works by mimicking glucagon-like peptide-1 (GLP-1), a hormone naturally produced in the gut, which regulates appetite, promotes satiety, and stabilizes blood sugar levels
The study is important because it confirms that GLP-1RA therapy has clinically meaningful systemic effects, reinforcing the need to understand how metabolic benefit is integrated with broader nutritional and physiological adaptation

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Yusta B, et al
