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The major benefits of switching include greater appetite suppression, continued weight loss after a plateau, and improved blood sugar control

Data show that in adult patients with type 2 diabetes with increased cardiovascular (CV) risk, compared with titrated insulin glargine, all three doses of tirzepatide show superiority in reducing blood sugar and body weight: treatment for 52 weeks, with curative effect Estimation (efficacy estimand) statistical analysis method, the highest dose of tirzepatide (15 mg, once a week) reduces blood glucose level (A1C) from baseline by 2.58%, and weight from baseline by 11.7 kg (25.8 pounds, 13.0%), and titration Insulin glargine reduced A1C from baseline by 1.44% and body weight increased by 1.9 kg (4.2 lbs, 2.2%) from baseline

The key issue is not the number of targets alone

These are astounding results given both the magnitude of the weight loss and the time frame in which it occurred (gradual weight loss over 1.3 years) as rapid weight loss is known to be unhealthy and subject to the yo-yo effect