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At 12 months, patients receiving exenatide had a mean improvement of 2.7 points, while the control group had a mean decline of 2.2 points, indicating a statistically significant difference of 4.9 points (95% CI, 0.3-9.4

doi: 10.1186/s13293-016-0059-9 10 WangWVolkowNDBergerNADavisPBKaelberDCXuR

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This is because the BBB is a highly selective biological barrier composed of specialized types of endothelial cells that form a tightly controlled barrier, protecting the brain from the influence of external substances