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Additionally, liraglutide increased IL-10 secretion and CD206 gene expression in human macrophages, which also promoted anti-inflammatory effect

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Following the Phase Ib readout, Zealand expects to initiate a mid-stage study for petrelintide imminently, with data expected by the end of 2025 or early 2026, as per the Leerink note

71 In addition, the length of exposure to GLP1RA could have been insufficient to detect some longerterm effects, increasing the chance of falsely negative results

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