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Tirzepatide (Mounjaro, Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist used for type 2 diabetes and chronic weight management

However, the critical takeaway is that combining these two powerful entities requires cautious consideration and, most importantly, expert medical guidance

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In a phase I clinical trial, patients who were overweight or obese were able to reduce their body weight by 4.8% (3 mg dosage), 6.4% (4.5 mg), and 6.0% (6 mg) after receiving a once-weekly dose of mazdutide [51]

These include pancreatitis, gastroparesis, gallbladder and biliary disease, and, in select cases, acute kidney injury related to dehydration