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Description
Gastrointestinal effects Beyond nausea, the full spectrum of GI side effects includes constipation, diarrhea, bloating, and abdominal discomfort

Although comparisons between tirzepatide and higher doses of dulaglutide (e.g., 4.5 mg) have yet to be done, these data argue against the concept that GIP coagonism can reduce the risk of GI adverse events

No, GLP-1 medications that have been frozen must be discarded even if subsequently thawed, as freezing permanently damages the peptide structure and compromises medication effectiveness

A recent Survey of Ophthalmology review synthesized findings from cardiovascular outcomes trials, retrospective database analyses, meta-analyses and preclinical studies involving semaglutide, liraglutide, dulaglutide and related agents across six ocular conditions: diabetic retinopathy (DR), glaucoma, nonarteritic anterior ischemic optic neuropathy (NAION), age-related macular degeneration (AMD), idiopathic intracranial hypertension (IIH) and dry eye disease (DED)

Conflating receptor agonism with receptor selectivity
