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Here, we studied the cellular sites of DPP-4 expression required for control of lipid metabolism in mice using gut-selective versus systemic inhibitory concentrations of the DPP4i sitagliptin (19, 20)
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In three different species (i.e., mice, rats, and musk shrews), we show that glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling blocks emesis and attenuates illness behaviors elicited by GLP-1R activation, while maintaining reduced food intake, body weight loss, and improved glucose tolerance
Banting FG, Best CH

Role of fat hydrolysis in regulating glucagonlike peptide1 secretion
