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Roux-en-Y gastric bypass surgery suppresses hepatic gluconeogenesis and increases intestinal gluconeogenesis in a T2DM rat model

[7] [8] Whilst this reduction in appetite is central to Wegovy's effectiveness, it also introduces a nutritional challenge: when people eat considerably less, they risk consuming insufficient protein

There were also improvements in DLQI (21.8 6 points to 4.1 3.9 points) and PASI (15.7 11.8 points to 2.2 3.0 points) [76]

Specifically, it suggests that GLP-1 drugs could act upon impulse control and stress-reward systems in the brain relating to substance and alcohol misuse