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Cases like this one show why molecular depth matters - patient by patient

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Nedd4 fl/fl mice containing LoxP sites flanking exon 9 were bred with Aldh1l1 CreER mice to generate Nedd4 fl/fl - Aldh1l1 CreER and Nedd4 fl/fl littermates for experiments

Even though additional physicochemical properties play important roles, placental transfer of drugs with such high molecular size is generally not anticipated in the first trimester of pregnancy, unless a specific mechanism for transfer exists

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