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Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity: The STEP 4 Randomized Clinical Trial

Clinical Evidence: Weight Loss Thresholds and Plantar Fasciitis Symptom Resolution Multiple observational cohorts of patients on GLP-1 therapy report symptom improvement correlating with cumulative weight loss milestones

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The increased energy expenditure and enhanced fat oxidation from glucagon activation may produce a more favorable body composition outcome, preserving more lean mass while targeting fat stores preferentially