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Ignoring constipation early: Once constipation becomes severe, it is harder to correct

JAMA 310 (22), 24162425 (2013) S

Before taking either supplement, you should discuss with your doctor to see if a different dosage would be more appropriate

It should be taken daily, on an empty stomach, with 4 ounces of water, and no other food or liquids may be consumed for at least 30 minutes

Topamax (Topiramate) Prescribing Information