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Handbook, H

Microdose GLP-1 protocols or compounded semaglutide injection (a GLP-1-only agonist without GIP activation) may also present lower risk if your clinician recommends avoiding the dual-receptor mechanism

In fact, indirect inhibition of GLP-1 secretion via sc injection of octreotide, a somatostatin analog, enhances computer mouse clicks for chocolate rewards in individuals who underwent RYGB surgery but not in obese non-operated controls, suggesting that RYGB surgery influences the effects of GLP-1 signaling on food-motivated responses [99]

J Biol Chem 1992

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Wadden T.A., Hollander P., Klein S., Niswender K., Woo V., Hale P.M., Aronne L., NN8022-1923 Investigators Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: The SCALE Maintenance randomized study