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Case 2: Due to a national shortage of 1.0 mg semaglutide, a female whose weight was previously stable on phentermine 15mg/topiramate 25mg twice daily plus GLP-1 agonist therapy (i.e., semaglutide) was switched to 5mg tirzepatide in-between clinic visits
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At presentation, persons with ketosis-prone T2D have significant impairment of both insulin secretion and insulin action
Patients with favorable genetic profiles for sustained GLP-1 response often experience durable weight loss and improved metabolic markers over years of continuous treatment
