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therefore, substantial weight reduction may naturally raise endogenous testosterone, potentially requiring dose adjustments in those on testosterone replacement therapy (TRT)

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Sakurain T, Amemiya A, Ischi M, et al

Right now, some have to come off the medications due to prohibitive costs and benefits running out, he says
In murine models of metabolic syndrome and diet-induced obesity, SLU-PP-332 reduces fat mass, improves lipid parameters, and remodels liver steatosis signatures while shifting respiratory exchange ratio toward greater lipid use
