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Common listed tirzepatide side effects Some common side effects associated with tirzepatide use include: Accelerated heartbeat Chronic fever Constipation Diarrhea Face, throat or tongue swelling Feelings of fullness Heartburn Itching, redness or rash of the skin Stomach pain Trouble breathing or swallowing Vomiting Yellowed eyes or skin Some side effects of tirzepatide can be indicative of severe health conditions, such as: Acute kidney injury (AKI): AKI is a condition that causes the kidneys to stop filtering waste from the blood