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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily used to manage type 2 diabetes and, in some formulations, obesity

For example, if one population activated by factor X projects specifically to the amygdala but another activated by factor Y to the VTA, it would be possible to achieve more precise and selective VTA GLP-1R activation by simply applying factor Y

Samhani C, Guerci B, Larose C

Plasma was isolated by centrifugation at 17,000 g for 5 min at 4 C and diluted 1:10 in 50% (v/v) glycerol in PBS (pH 7.4) (Sigma-Aldrich) for storage at 20 C until analysis

Mechanistic Studies in Neurodegeneration: Further elucidation of GLP-1RAs neuroprotective mechanisms (eg, anti-inflammatory effects, amelioration of cerebral insulin resistance) is warranted, along with evaluation of the neuropsychiatric potential of GLP-1/GIP dual agonists