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Among the reported findings after 12 weeks: BMI: 27.13 vs 28.49 Waist circumference: 88.32 cm vs 92.21 cm Fasting plasma glucose: 6.59 vs 7.68 mmol/L 2-hour postprandial glucose: 8.24 vs 10.13 mmol/L HbA1c: 6.69% vs 7.13% HOMA-: 50.03 vs 31.26 The paper also reported greater reductions in total cholesterol and triglycerides in the dorzagliatin combination arm, while adverse event rates were similar between the two groups

Derek Thompson: How long did it take Lilly to recognize that what had begun as a type 2 diabetes drug was in fact an incredibly powerful weight-loss drug

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Weight maintenance is individualized: some patients stop, some cycle back on, and others stay on a lower maintenance dose

Welch A et al