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While many of these medications can lead to weight loss, their primary approval and prescription purpose should always be discussed with your doctor

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placebo in adults with overweight or obesity without diabetes (STEP 3), mean body weight decreased 16.0% with semaglutide compared with 5.7% with placebo, both as adjunct to intensive behavioral therapy (ETD 10.3%

Despite the contradictory data regarding kidney outcomes, two surrogate outcomes benefit the most from combined therapy: the decline in eGFR slope and the reduction in urinary albumin-to-creatinine ratio