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GLP-1 is produced in the gut after we eat a meal and helps to lower blood sugar levels by stimulating the production of insulin and suppressing the release of the hormone glucagon

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These drugs significantly reduced rates of #coloncancer (16% fewer cases) and #rectalcancer (28% fewer cases), among others like post-menopausal #breastcancer, #endometrialcancer, and #pancreaticcancer

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Given the promising results in pre-clinical models (even in the absence of T2D), a unique mechanism of action and multiple age-related reduced disease risks that have been reported with acarbose, support for clinical trials with acarbose focusing on aging-related outcomes and incorporating biological sex, age at treatment initiation, and T2D-dependence within the design is warranted.