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Major semaglutide trials (STEP program) documented nausea, vomiting, and gastrointestinal events as primary side effects

Results Liraglutide and GUB09-145 improve metabolic parameters in DIO mice Following 35 weeks of feeding, DIO mice showed significantly increased body weight (53.0 0.6 g, n = 45) compared to chow controls (32.1 0.2 g, n = 10, p 0.05) following treatment with vehicle, liraglutide or GUB09-145 as compared to baseline (Fig

These events are typically dose-dependent and occur most often during treatment initiation or dose escalation

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Another interesting MERCS function is related to lipid synthesis